Trans-resveratrol was shown by multiple studies to increase brain-derived neurotrophic factor (BDNF) and improve neural stem cell functions, neurogenesis, HPA axis signaling, executive function, learning and memory, neuroimmune signaling, and more. Even very small doses can improve insulin sensitivity to some extent, especially in obese and unhealthy individuals. A small decrease in fasting insulin and blood glucose was also found in one study.